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Citation: ZHONG Bin, LI Zheng-Ming, HAN Liang, WANG Su-Hua. Synthesis and Biological Activity of Polysubstituted Pyridine Derivatives[2][J]. Chinese Journal of Applied Chemistry, ;2005, 22(12): 1354-1356. shu

Synthesis and Biological Activity of Polysubstituted Pyridine Derivatives[2]

1.
State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071

Corresponding author: LI Zheng-Ming,
Received Date: 18 February 2005
Available Online: 26 June 2005
Fund Project: 国家重点基础研究发展计划("九七三"计划)(2003CB114400) ("九七三"计划)(2003CB114400)国家自然科学基金重点项目(20432010)资助项目 (20432010)

In an attempt to search for novel compounds with agricultural bioactivity,a series of new polysubstituted pyridine derivatives,α-[2-methyl-5-cyano4-(furan-2-yl)-3-ethoxycarboxyl-pyridine-6-thio]acetamide 4a, 2-methyl-5-cyano-4-(furan-2-yl)-3-acetyl pyridine-6-thioethers 5 and 6a were designed and synthesized by a three-step or one-step synthetic route.The structures of all the compounds prepared were confirmed by elemental analysis and ¹H NMR.The preliminary bioassay results indicate that compound 4a possesses certain fungicidal and herbicidal activities.
- polysubstituted pyridine,
- synthesis,
- biological activity
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