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Citation: LIN Wei-Feng, KANG Xin-Huang, CHEN Zuan-Guang, YANG Li, CAI Pei-Xiang, MO Jin-Yua. Determination of Captopril in Body Fluid by Capillary Electrophoresis with Ether Extraction[J]. Chinese Journal of Applied Chemistry, ;2006, 23(2): 136-139. shu

Determination of Captopril in Body Fluid by Capillary Electrophoresis with Ether Extraction

1.
a School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou;
2.
b School of Pharmaceutical Science, Sun Yat-sen University, Guangzhou 510089

Received Date: 25 April 2005
Available Online: 29 July 2005
Fund Project: 国家自然科学基金资助项目(20375049) (20375049)广东省自然科学基金重点项目(021808) (021808)

A method based on capillary electrophoresis with high frequency conductivity detection was developed for the determination of captopril in body fluids.In this study,key factors for the separation and determination were studied and the best analysis conditions were obtained.In a buffer system of 3.0 mmol/L cyclohexylamine +5.0 mmol/L boric acid +0.50 mol/L ethanol,when 20.0 kV was used as the separation potential,the optimal separation was obtained.Under the chosen conditions,captopril was eluted within 8 min.
- capillary electrophoresis,
- high frequency conductivity detection,
- contactless conductivity detection,
- captopril,
- captopril
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