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Citation: HU Guo-Qiang, XIE Song-Qiang, DU Gang-Jun, HUANG Wen-Long, ZHANG Hui-Bin, HUANG Sheng-Tang. Syntheses and Antibacterial Activities of Bis(amino-triazole sulfurether) and Their Piperonal Schiff's Base Derivatives[J]. Chinese Journal of Applied Chemistry, ;2006, 23(3): 273-277. shu

Syntheses and Antibacterial Activities of Bis(amino-triazole sulfurether) and Their Piperonal Schiff's Base Derivatives

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a Medicinal College, Henan University, Kaifeng 475001;
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b Center of Drug Discovery, China Pharmaceutical University, Nanjing

Corresponding author: HU Guo-Qiang,
Received Date: 26 May 2005
Available Online: 2 August 2005
Fund Project: 国家自然科学基金(30070861) (30070861)河南大学科研基金(04ZDZR009)资助项目 (04ZDZR009)

Bis(amino-triazole sulfurethers)(2a~2n) and the corresponding piperonal schiff's base derivatives(3a~3n) were synthesized via the condensation of amino-triazole thiols(1a~1n) with 1,2-dibromoenthane to obtain 2a~2n followed by the condensation of compounds 2a~2n with piperonal in acetic acid,respectively.The compounds were confirmed by IR,¹H NMR,MS and elemental analysis.Among the new compounds synthesized,the sulfurether compounds(2c),(2m) exhibit strong inhibiting activity against Staphylococcus aureus,and compound 2g does against Proteus vulgaris in dosage of 1.0×10^-4(mass fraction);the schiff's base compounds 3a~3j exhibit stronger inhibiting activity to Escherichia.coli,while they exhibit medium inhibiting activity to Staphylococcus aureus.
- s-triazole,
- sulfur ether,
- schiff's base,
- antibacterial activity
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