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Citation: GUO Sheng-Jin, LUO Kui, ZHANG Shi-Yong, LAN Jing-Bo, XIE Ru-Gang. Syntheses of Chiral Alkanoates and Alkanols with Imidazole Ring as Functional Site[J]. Chinese Journal of Applied Chemistry, ;2006, 23(4): 362-365. shu

Syntheses of Chiral Alkanoates and Alkanols with Imidazole Ring as Functional Site

1.
a Department of Chemistry, Sichuan University, Chengdu 610064;
2.
b Department of Bioscience and Technology, Jinzhong College, Yuci

Corresponding author: XIE Ru-Gang,
Received Date: 29 June 2005
Available Online: 19 August 2005
Fund Project: 国家自然科学基金资助项目(20472057) (20472057)

The sodium salts of (S)-2-(1-imidazolyl)alkanoic acids(2) were prepared by the cyclization of natural amino acids with formaldehyde aqueous solution and glyoxal aqueous solution under basic condition.The sodium salts(2) were esterified to form (S)-2-(1-imidazolyl)alkanoates(3a~3g).The (S)-2-(1-imidazolyl)alkanols(4a~4e) were obtaind by reduction of 3a~3e via NaBH₄ with satisfactory yields.The structures of the compounds(3a~3g,4a~4e) were confirmed by IR,¹H NMR,MS,and elemental analysis.
- natural amino acid,
- chiral imidazolylalkanoate,
- chiral imidazolylalkanol,
- synthesis
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