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Citation: XU Qian-Hui, WEI Ping. The Synthesis of DL-tryptophan with Gramine[J]. Chinese Journal of Applied Chemistry, ;2006, 23(6): 668-671. shu

The Synthesis of DL-tryptophan with Gramine

XU Qian-Hui ^a,, ,
WEI Ping ^b

1.
a Department of Chemical Engineering, ituaihai Institute of Technology, Lianyungang 222005;
2.
b College of Pharmacy and Life Science, Nanjing University of Technology, Nanjing

Corresponding author: XU Qian-Hui,
Received Date: 7 August 2005
Available Online: 30 October 2005

DL-tryptophan was synthesizd by condensing gramine with hydantoin and subsequent hydrolyzation of 5-(3-indole-methyl)hydantoin intermediate.The yield of DL-tryptophan to gramine was up to 41.6%.The optimum conditions of condensation were: 10 h reaction time,1.2:0.8:1 molar ratio of CH₃I to C₂H₅ONa to gramine,0.9:1 molar ratio of gramine to hydantoin.The optimum conditions of hydrolysis were: 1.5 mol/L NaOH,10 h hydrolysis time,0.2 mol/L 5-(3-indolemethyl)hydantoin,and 100℃ reaction temperature.
- DL-tryptophan,
- gramine,
- (indolemethyl)hydantoin,
- synthesis
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