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Citation: CHEN Chang-Yun, LI Xiao-Hua, SHAN Yun, XIA Juan, XIANG Bing-Ren. Studies on the Binding among Co(phen)₃²⁺,Prulifloxacin and DNA by Means of Spectroscopic and Voltammetric Methods[J]. Chinese Journal of Applied Chemistry, ;2006, 23(7): 818-820. shu

Studies on the Binding among Co(phen)₃²⁺,Prulifloxacin and DNA by Means of Spectroscopic and Voltammetric Methods

1.
a Center of Analysis, China Pharmaceutical University, Nanjing 210009;
2.
b Department of Chemistry, Nanjing Xiaozhuang University, Nanjing

Corresponding author: XIANG Bing-Ren,
Received Date: 10 September 2005
Available Online: 25 November 2005

The binding among Co(phen)₃²⁺,prulifloxacin and calf thymus DNA in Tris buffer solution(pH=7.4) were investigated by means of cyclic voltammetry and UV spectroscopy.The UV results showed prulifloxacin and Co(phen)₃²⁺ formed a binary complex with a binding constant of 2.0×10⁴ L/mol.After adding DNA,the binary complex continued to combine with DNA.The electrochemical results indicated that the peak current decreased in the presence of DNA;the peak potential difference was increased by 17 mV;formal potential shifted 3.5 mV negatively.The results show that the binding mode of Co(phen)₃²⁺-prulifloxacin binary complex and DNA was mainly electrostatic interaction.
- prulifloxacin,
- Co(phen)₃²⁺,
- CT-DNA,
- binding
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Studies on the Binding among Co(phen)32+,Prulifloxacin and DNA by Means of Spectroscopic and Voltammetric Methods

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通讯作者: 陈斌, bchen63@163.com

Studies on the Binding among Co(phen)₃²⁺,Prulifloxacin and DNA by Means of Spectroscopic and Voltammetric Methods