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Citation: LI De-Jiang, FU He-Qing, GE Zheng-Hong. Synthesis and Antibacterial Activities of 2-Aryl-3-N-Propanoyl-5-(2-Bromo-4-Fluorophenyl)1,3,4-Oxadiazoline Derivatives[J]. Chinese Journal of Applied Chemistry, ;2006, 23(8): 936-938. shu

Synthesis and Antibacterial Activities of 2-Aryl-3-N-Propanoyl-5-(2-Bromo-4-Fluorophenyl)1,3,4-Oxadiazoline Derivatives

1.
a Department of Chemistry, Yunyang Normal College, Danjiangkou 442700;
2.
b Institute of Chemical Engineering, South China University of Technology, Guangzhou;
3.
c Department of Pharmaceutical Technology, Jiangsu Institute of Industry, Changzhou

Corresponding author: LI De-Jiang,
Received Date: 12 October 2005
Available Online: 16 December 2005
Fund Project: 湖北省教育厅2004年科学技术研究项目(2004D001) (2004D001)

Condensation of 2-bromo-4-fluorobenzoyl hydrazine(1) with aromatic aldehydes produced corresponding hydrazones(2a~2i).Cyclization of 2a~2i with propanoic anhydide gave the title compounds 3a~3i in good yields of 79.3%~85.5%.Their structures were characterized by means of elemental analysis,IR,¹H NMR and MS spectra.The preliminary antibacterial tests showed that most of them had good antibacterial activities.
- oxadiazoline derivative,
- synthesis,
- structural characterization,
- antibacterial activity
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