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Citation: LAN Wen-Jian, LI Hou-Jin. Chemical Composition of Oldenlandia cantonensis How[J]. Chinese Journal of Applied Chemistry, ;2006, 23(8): 871-874. shu

Chemical Composition of Oldenlandia cantonensis How

LAN Wen-Jian ^a ,
LI Hou-Jin ^b,,

1.
a School of Pharmaceutical Science;
2.
b School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275

Corresponding author: LI Hou-Jin,
Received Date: 14 September 2005
Available Online: 14 February 2006
Fund Project: 国家自然科学基金(20502036) (20502036)广东省自然科学基金(05300667) (05300667)中山大学青年教师科研启动基金(2004-36000-1131072)资助项目 (2004-36000-1131072)

The chemical composition of Oldenlandia cantonensis How,a herbal medicine is reported.A new pentacyclic triterpenoid,urs-12-en-29α-oic acid-3β-ol was obtained from the EtOAc-eluted fraction of the ethanol extract of Oldenlandia cantonensis How.The structure was elucidated by spectroscopy methods, including NMR(1D and 2D),IR,and MS.Urs-12-en-29α-oic acid-3β-ol exhibited potent inhibiting effect against the human DNA topoisomerase Ⅰ(hTopo Ⅰ),the cancer cell lines BEL-7402,and MCG-803, with the IC₅₀ values 12.0×10^-6,6.5×10^-6 and 8.0×10^-6 g/mL,respectively.The low polarity fatty oil,the eluted fraction of V(petroleum ether):V(EtOAc)=20:1 was also quantitatively analyzed by gas chromato-graphy mass spectrometry(GC-MS).As a result,60 compounds were detected.The fatty oil mainly composed of long chain aliphatics,terpene and steroid compounds,with percentages of 36.16%,6.42% and 9.28%,respectively.
- Oldenlandia cantonensis How,
- chemical constituents,
- urs-en-29α-oic acid-3β-ol,
- bioactivity
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