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Citation: LU Jun, YANG Hai-Lang, ZHAO Liang-Jun, XIAO Chao-Bo. Regioselective Synthesis of Monolauryl Citrate[J]. Chinese Journal of Applied Chemistry, ;2006, 23(10): 1176-1178. shu

Regioselective Synthesis of Monolauryl Citrate

1.
a Department of Chemistry and Bioscience, Xiangfan University, Xiangfan 441003;
2.
b College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072

Corresponding author: LU Jun,
Received Date: 5 December 2005
Available Online: 4 March 2006
Fund Project: 湖北省教育厅重点科研基金资助项目(D200525003) (D200525003)

Monolauryl citrate was synthesized by regioselective esterification.Reaction of citric acid with paraformaldehyde gave anhydromethylene citric acid(Ⅰ) with a yield of 63%;the reaction of compound(Ⅰ) with acetic anhydride gave the corresponding anhydride(Ⅱ) with a yield of 87%;the esterification of compound(Ⅱ) with lauryl alcohol gave anhydrocitric acid monoester(Ⅲ) with a yield of 76%.Refluxing(Ⅲ) with 1 equivalent of base in aqueous dioxane,the monolauryl citrate was obtained with a yield of 83%.All the compounds were characterized by means of ¹H NMR,IR and Elemental Analysis.
- regioselective,
- anhydromethylene citric acid,
- citric acid monoester,
- synthesis
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