引用本文:
张永强, 沈宗旋, 张雅文. 基于辛可宁的几种手性季铵盐的合成及对查尔酮的催化不对称环氧化[J]. 应用化学,
2006, 23(11): 1233-1236.
Citation: ZHANG Yong-Qiang, SHEN Zong-Xuan, ZHANG Ya-Wen. Synthesis and Application in Enantioselective Epoxidation of Chalcone of Chiral Quaternary Ammonium Salts Based on Cinchonine[J]. Chinese Journal of Applied Chemistry, 2006, 23(11): 1233-1236.
Citation: ZHANG Yong-Qiang, SHEN Zong-Xuan, ZHANG Ya-Wen. Synthesis and Application in Enantioselective Epoxidation of Chalcone of Chiral Quaternary Ammonium Salts Based on Cinchonine[J]. Chinese Journal of Applied Chemistry, 2006, 23(11): 1233-1236.
基于辛可宁的几种手性季铵盐的合成及对查尔酮的催化不对称环氧化
English
Synthesis and Application in Enantioselective Epoxidation of Chalcone of Chiral Quaternary Ammonium Salts Based on Cinchonine
Abstract:
A new chiral quaternary ammonium salt 1a was synthesized by the reaction of cinchonine and 2,4,6-trimethyl benzyl chloride.Etherification between 1a and benzyl bromide,allyl chloride,or methyl iodide give corresponding etherified quaternary ammonium salts 1b,1c,and 1d.In the presence of 1b,1c,or 1d(5%,molar fraction),chalcone was stereoselectively epoxidized by sodium hypochlorite with yields range from 89% to 92% and ee range from 58% to 63%.
-
Key words:
- chiral phase-transfer catalyst
- / synthesis
- / etherification
- / asymmetric epoxidation
- / chalcone
-
-
扫一扫看文章
计量
- PDF下载量: 1
- 文章访问数: 1266
- HTML全文浏览量: 246
下载:
