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Citation: SU Jiang-Tao, KONG Fan-Lei, LI Zhao-Ying, HU Xian-Ming. Synthesis, Characterization and Anticonvulsion Activity of Two Novel Cyclopropyl Spiro thiobarbitur Derivatives[J]. Chinese Journal of Applied Chemistry, ;2006, 23(12): 1416-1418. shu

Synthesis, Characterization and Anticonvulsion Activity of Two Novel Cyclopropyl Spiro thiobarbitur Derivatives

1.
a Jiangsu Agrochem Laboratory, Changzhou 213022;
2.
b Chemistry and Molecule Science College, Wuhan University, Wuhan;
3.
c College of Pharmacy, Wuhan University, Wuhan

Corresponding author: SU Jiang-Tao,
Received Date: 25 November 2005
Available Online: 24 January 2006

Two cyclopropyl spiro thiobarbiturs with rigid configurations were designed,synthesized and characterized by IR and NMR.The difference in the chemical shift of N-H between compounds 1a and 1b was observed.The rigid structure was also proved by the relation between the proton (-CH₂-) in the cyclopropane ring and the nearest proton (N-H) in the bartitur ring on ¹H-¹H COSY map due to the shielding effect of the two rings.The anticonvulsion activities of the two novel compounds 1a and 1b were also tested and the restrain ratio was 50% and 70% respectively.
- cyclopropane,
- spiro,
- thiobarbitur,
- anticonvulsion activity
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