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Citation: LIU Xin-Hua, WANG Shi-Fan, SONG Bao-An, BAI Lin-Shan. Synthesis and Bactericidal Activities of Novel Pyrazole-1-carbothioamide Derivatives[J]. Chinese Journal of Applied Chemistry, ;2006, 23(12): 1355-1358. shu

Synthesis and Bactericidal Activities of Novel Pyrazole-1-carbothioamide Derivatives

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a School of Chemistry and Chemical Engineering, Anhui University of Technology, Maanshan 243002;
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b State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing;
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c Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Guiyang

Corresponding author: LIU Xin-Hua,
Received Date: 16 December 2005
Available Online: 15 April 2006
Fund Project: 安徽省高等学校青年教师科研资助项目(2005JQ1075) (2005JQ1075)安徽省高等学校自然科学研究项目(2006KJ104B) (2006KJ104B)

4-(2-Hydroxy-phenyl)-but-3-en-2-one was prepared via condensation of salicylaldehyde with acetone,and then cyclization of the α,β-unsaturated ketones with thiosemicarbzide.Seven new 5-(2-hydroxyphenyl)-3-methyl-4,5-dihydropyrazole-1-carbothioamide derivatives were synthesized and characterized by means of elemental analysis,IR and ¹H NMR.The compounds 3c,3d,3g showed certain bactericidal activity against E. coli;compound 3g show certain bactericidal activity against P.vulgaris.
- pyrazole,
- carbothioamide,
- bioactivity
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