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Citation: LI Quan-Wen, CHEN Zuan-Guang, ZHOU Xie, WEI Li-Ping. Determination of Miconazole Nitrate in Medicines by Capillary Electrophoresis[J]. Chinese Journal of Applied Chemistry, ;2006, 23(12): 1317-1322. shu

Determination of Miconazole Nitrate in Medicines by Capillary Electrophoresis

1.
a School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510089;
2.
b Nanfang Medical University, Guangzhou

Corresponding author: CHEN Zuan-Guang,
Received Date: 19 December 2005
Available Online: 30 May 2006
Fund Project: 国家自然科学基金资助项目(20375049) (20375049)广东省自然科学基金重点项目(021808) (021808)

A method for the determination of miconazole nitrate in two different medicines by capillary electrophoresis with high frequency conductivity detection(contactless conductivity detection) was established.The electrophoretic parameters, such as the variety and concentration of buffer solution,separation voltage etc,were researched.Miconazole nitrate was separated and detected in a buffer(3.0 mmol/L lactic acid+10% ethanol(pH=4.0)) at 20.0 kV constant voltage.The linear dependence of the concentrations of miconazole nitrate ranged from 20.0 to 900 mg/L(r=0.999 4),and the limit of detection(LOD) reached 1.0 mg/L (S/N=)3.The RSDs for both intra-day and inter-day were less than 3% and the recoveries were 94.9%~101% and 95.3%~99.1% for Miconazole-nitrate-cream and Miconazole-nitrate-vaginal-suppositories suppository respectively at various spiked levels.This method may be useful for the determination of miconazole nitrate in compound preparations.It could be used for quality control of products due to its simplicity,rapidity and sensitivity.
- capillary electrophoresis,
- high frequency conductivity detection,
- contactless conductivity detection,
- miconazole nitrate,
- compound preparations
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