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Citation: LIU Kai-Min, ZHANG Jun, XING Geng-Mei, ZHAO Yu-Liang. Synthesis and Usage of Gd@C₈₂(OH)₁₆ as MRI Contrast Agent[J]. Chinese Journal of Applied Chemistry, ;2007, 24(1): 90-94. shu

Synthesis and Usage of Gd@C₈₂(OH)₁₆ as MRI Contrast Agent

1.
a School of Life Science and Technology, Beijing Institute of Technology, Beijing 100081;
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b Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Science, Beijing 100049

Corresponding author: ZHANG Jun,
Received Date: 23 January 2006
Available Online: 23 July 2006

Metallofullerene Gd@C₈₂ was synthesized via electric arc method and separated by two-step HPLC with 95% purity, and its derivative Gd@C₈₂(OH)_x was synthesized by the reaction of Gd@C₈₂ with NaOH catalyzed by tetrabutylammonium hydroxide(TBAH).The hydroxyl number of Gd@C₈₂(OH)_x was determined by XPS on its C_1s spectrum and the compound was assigned as Gd@C₈₂(OH)₁₆.The proton relaxivity and MRI photographs of Gd@C₈₂(OH)₁₆ were evaluated in vitro and in vivo on a Bruker 4.7T/30 cm Biospec magnetic resonance imaging scanner.Results show that Gd@C₈₂(OH)₁₆ has a high proton relaxivity in vitro, even higher than that of (NMG)₂-Gd-DTPA, which is the most popularly used MRI contrast agent clinically.Compared to that of (NMG)₂-Gd-DTPA, relaxitivity R₁ of Gd@C₈₂(OH)₁₆ increased 3 times, relaxitivity R₂ increased 7 times.In vivo experiments found Gd@C₈₂(OH)₁₆ helped to generate high quality MRI photographs.The bio-distribution results indicate that Gd@C₈₂(OH)₁₆ tends to be entrapped in the liver and kidney and remained in these organs for about 2 hours.These results indicate that the metallofullerene derivative Gd@C₈₂(OH)₁₆ might be the potential candidate as a new MRI contrast agent.
- metallofullerene,
- Gd@C₈₂(OH)₁₆,
- relaxivity,
- MRI contrast agent
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Synthesis and Usage of Gd@C₈₂(OH)₁₆ as MRI Contrast Agent