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Citation: SHEN Fang, LIANG Jing-Juan, LIU Xiong-Min. Lipase-catalyzed Synthesis of Cyclopentadecanolide from Methyl ω-Hydroxy-pentadecanate[J]. Chinese Journal of Applied Chemistry, ;2007, 24(1): 63-66. shu

Lipase-catalyzed Synthesis of Cyclopentadecanolide from Methyl ω-Hydroxy-pentadecanate

1.
a Chemistry and Chemical Engineering Academy, Guangxi University, Nanning 530004;
2.
b College of Life Science & Technology, Guangxi University, Nanning 530004

Corresponding author: LIU Xiong-Min,
Received Date: 21 January 2006
Available Online: 8 April 2006
Fund Project: 教育部科学技术研究重点项目(204110) (204110)广西自然科学基金资助项目(桂科自0135013) (桂科自0135013)

One kind of screened lipase from Candida sp.CXU08 was used as a catalyst to synthesize cyclopen-tadecanolide.Methyl ω-hydroxy-pentadecanate was used as the substrate.The effects of activity of lipase, time of reaction, temperature, pH, dielectric constant of organic solvent etc on the conversion of ω-hydroxy-pentadecanate were studied.The results indicate that GXU08 has a good specificity and no cyclononalide, cyclotridecanolide or other polymers were found.Under the optimum reaction conditions: 40℃, 180 r/min, pH=6.0, activity of lipase 1 245 U, 72 h, the conversion is 17% in cyclohexane.
- lipase,
- cyclopentadecanolide,
- methyl ω-hydroxy-pentadnecanate,
- catalysis
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