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Citation: ZHAO Chang-Zhi, ZHANG Zhi-Hui, GE Tong, JIAO Kui. Glucose Sensor Without Enzyme[J]. Chinese Journal of Applied Chemistry, ;2007, 24(2): 192-195. shu

Glucose Sensor Without Enzyme

ZHAO Chang-Zhi ^a,b,, ,
ZHANG Zhi-Hui ^b ,
GE Tong ^a ,
JIAO Kui ^a

1.
a College of Chemistry & Molecular Engineering, Qingdao University of Science & Technology, Qingdao 266042;
2.
b School of Chemical Engineering, Dalian University of Technology, Dalian 116012

Corresponding author: ZHAO Chang-Zhi,
Received Date: 3 March 2006
Available Online: 10 June 2006

A novel glucose sensor without enzyme was prepared based on the electrochemical oxidation of glucose at a nickel electrode.The mechanism of electrochemical oxidation and response of the sensor to glucose was investigated.In the alkaline solution,the Ni(Ⅲ) species of nickel electrode surface acts as a oxidant for the oxidation of glucose,the glucose is quickly oxidized to glucolactone by the Ni(Ⅲ) species, resulting to the increase of current,which can quantify the concentrations of glucose.The sensor was composed of a nickel rod working electrode,a platinum counter electrode and an Ag/AgCl reference elec-trode.The wave potential of the electrochemical oxidation at 570 mV was employed as the working potential of the sensor.The response time of the sensor is less than 60 seconds and the time of monitoring a sample is 3 minutes.The current response of the sensor is proportional to the concentration of glucose,the detecting range is from 1.96×10^-5 to 1.80×10^-4mol/L,with a detection limit of 9.80×10^-6mol/L.Because the sensor does not contain enzyme,the effect of temperature is less and oxygen in sample does not affect the determination of glucose.Dopamine,ascorbic acid and urea acid do not interfere with the determination of glucose due to their inactivation at nickel electrode.The sensor has been applied to the determination of prac-tical samples,the relative standard deviation(RSD) is less than 4.3%(n=5) for the determination of glucose in human blood serum and the result is consistent with that from the hexokinase method.The preparation of the sensor is simple and has a lower cost,as well as it can be repeatedly used after simple treatment.
- Glucose sensor,
- electrochemical oxidation,
- nickel electrode
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