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Citation: LI Sheng, HU Guo-Qiang, XIE Song-Qiang, HUANG Wen-Long, ZHANG Hui-Bin. Syntheses and Antibacterial Activities of s-Triazole Salicylaldimine Schiff-bases Containing Oxadiazole Oxime-ether Subunits[J]. Chinese Journal of Applied Chemistry, ;2007, 24(3): 310-313. shu

Syntheses and Antibacterial Activities of s-Triazole Salicylaldimine Schiff-bases Containing Oxadiazole Oxime-ether Subunits

1.
a Institute of Pharmacy, Nanjing 210009;
2.
b Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009;
3.
c Center of Drug Discovery, China Pharmaceutical University, Nanjing

Corresponding author: LI Sheng,
Received Date: 23 March 2006
Available Online: 3 June 2006
Fund Project: 河南大学重点科研基金资助项目(04ZDZR009) (04ZDZR009)

The reaction of 4-amino-3-phenyl-5-mercapto-s-triazole(1) with β-chloro-phenyl-propanone(2) under refluxing ethanol in the presence of sodium acetate gave amino-triazolyl sulfanyl-phenylpropanone(3). The oximation of compound 3 with hydroxyamine hydrochloride yielded the corresponding oxime(4) followed by the etherification with each of chloromethy-oxadiazoles(5a~5e) and the condensation with salicylaldehyde to form oxime-ethers(6a~6e) and schiff-base oxime-ethers(7a~7e), respectively. The antibacterial activities of the compounds synthesized in vitro to Gram positive bacteria and Gram negative bacteria were tested with the standard 2-fold agar dilution method, and all the tested compounds exhibited relatively better activities against Gram positive bacteria than those against Gram negative bacteria.
- s-triazole,
- oxadiazole,
- omixe-ether,
- Schiff-base,
- synthesis,
- antibacterial activity
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