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Citation: REN Yi-Ming, CAI Chun. Iodine-Mediated Synthesis of Benzimidazoles[J]. Chinese Journal of Applied Chemistry, ;2007, 24(7): 847-849. shu

Iodine-Mediated Synthesis of Benzimidazoles

REN Yi-Ming ,
CAI Chun ^,

1.
Chemical Engineering College, Nanjing University of Science & Technology, Nanjing 210094

Corresponding author: CAI Chun,
Received Date: 10 August 2006
Available Online: 1 November 2006

The present paper describes a direct one-step synthesis of various benzimidazoles from primary alcohols and o-phenylenediamine with good yields using iodine as the catalyst.The influence of reaction conditions such as the ratio of I₂ and K₂CO₃,and temperature was studied.The yield of 2-(o-chlorophenyl) benzi-midazole was 86% via method A under the optimized reaction conditions,which were 70℃,n(o-ClC₆H₄CH₂OH):n(o-phenylenediamine):n(I₂):n(K₂CO₃)=1.0:1.1:5.0:5.0,and 5 h.The yield of 2-(o-chlorophenyl) benzimidazole was 69% via method B.In our work primary alcohols were used as the starting material instead of acids or aldehydes in the reported procedures.The present method is relatively simple and the reaction condition is mild.It is a new method for preparing benzimidazoles.A possible reaction mechanism is proposed as well.
- iodine,
- benzimidazoles,
- primary alcohol,
- o-phenylenediamine
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