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Citation: JI Ya-Fei, XU Xu. Simple Synthesis of Adenosine from Inosine[J]. Chinese Journal of Applied Chemistry, ;2007, 24(8): 971-973. shu

Simple Synthesis of Adenosine from Inosine

JI Ya-Fei ^a,, ,
XU Xu ^b

1.
a School of Pharmacy, East China University of Science and Technology, Shanghai 200237;
2.
b College of Chemical Engineering, East China University of Science and Technology, Shanghai 200237

Corresponding author: JI Ya-Fei,
Received Date: 3 September 2006
Available Online: 13 December 2006
Fund Project:

A synthetic process of adenosine was performed from inosine by a conversion of functional groups with an overall yield of 62%.With sodium acetate as catalyst,inosine was esterified with acetic anhydride in the yield of 92% to give 2',3',5'-triacetyl inosine,which was treated with pyridine and phosphorus oxychloride to form a pyridinium solution,followed by performing an amination at 40℃ and 0.25~0.30 MPa to achieve adenosine in the yield of 67%.The structure of adenosine was confirmed by means of ¹H NMR,MS.This simple synthesis of adenosine is accessible to an industrial scale.
- adenosine,
- inosine,
- nucleoside,
- synthesis
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