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Citation: JIANG Dong, LI Wei, XU Cheng-Di, DAI Li-Yi. Catalytic Synthesis of Aspirin in Brønsted Acid Ionic Liquids[J]. Chinese Journal of Applied Chemistry, ;2007, 24(9): 1080-1082. shu

Catalytic Synthesis of Aspirin in Brønsted Acid Ionic Liquids

JIANG Dong ^a ,
LI Wei ^b ,
XU Cheng-Di ^a ,
DAI Li-Yi ^a,,

1.
a Department of Chemistry, East China Normal University, Shanghai 200062;
2.
b Shandong University of Traditional Chinese Medicine, Ji'nan

Corresponding author: DAI Li-Yi,
Received Date: 16 September 2006
Available Online: 10 November 2006
Fund Project: 国家自然科学基金(20503016)资助项目 (20503016)教育部科技重点资助项目(105075) (105075)

Brønsted acid ionic liquids [Hmim]BF₄, [bmim]HSO₄ or [bmim]H₂PO₄ was used as substituted catalyst of oil of vitirol in the acylation of salicylic acid for the synthesis of Aspirin. The effects of reaction temperature, reaction time, amount of catalyst and molar ratio of salicylic acid to acetic anhydride on the acylation reaction and the reuseful ability of the ionic liquid were examined. The optimum reaction conditions were:the amount of [bmim]H₂PO₄ was 0.28 g(1.18×10^-3 mol), salicylic acid 2.762 g(0.02 mol), acetic anhydride 4.083 g(0.04 mol), molar ratio of anhydride to salicylic acid 2:1; the reaction time 30 min; the reaction temperature 70℃. The yield was 63.43%. After filtration and evaporation, [bmim]H₂PO₄ could be reused three times, no obvious change was observed in the yield.
- Aspirin,
- ionic liquid,
- catalysis
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