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Citation: LI Zhong-Hua, LI Jia-Feng, WANG Yan-Gang. Synthesis and Biological Activity of Carbazole Schiff Bases[J]. Chinese Journal of Applied Chemistry, ;2007, 24(9): 1074-1076. shu

Synthesis and Biological Activity of Carbazole Schiff Bases

1.
a College of Chemistry, Central China Normal University, Wuhan 430079;
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b School of Chemistry and Environmental Engineering, Hubei Institute for Nationalities, Enshi

Corresponding author: LI Zhong-Hua,
Received Date: 30 September 2006
Available Online: 26 November 2006
Fund Project: 国家自然科学基金资助项目(20072009) (20072009)

Carbazole was nitrosylated and reduced to aminocarbazole by the action of zinc in acetic acid. Nine novel carbazole schiff bases(1~9) were synthesized by the reaction of 9-aminocarbazole and substituted aromatic aldehydes with yields of 63%~87%. Their structures were characterized by IR, ¹H NMR, MS and elemental analysis. The preliminary test of bioactivity showed they displayed notable antibacterial activities. The bacterial inhibition of compounds 3 and 7 was more than 85%.
- schiff base,
- aminocarbazole,
- aromatic aldehyde,
- synthesis,
- antibacterial activity
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