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Citation: ZHANG Yong-Ke, ZHAO Jing-Chan, GUO Zhi-An, ZHANG Yan-Feng, HAN Bing. Qualitative and Quantitative Analyses of Micro-impurities in Medical HFC-134a[J]. Chinese Journal of Applied Chemistry, ;2007, 24(11): 1346-1348. shu

Qualitative and Quantitative Analyses of Micro-impurities in Medical HFC-134a

1.
Department of Chemistry, Northwest University, Xi'an 710069

Received Date: 30 November 2006
Available Online: 28 January 2007

The impurities in medical HFC-134a were qualitatively analyzed by GC-MS on HP-PLOT Al₂O₃S capillary column. GC-FID was used to quantitatively analyze the micro-impurities. The detection limits of the impurities were lower than 7.0×10^-7 g/L, and the relative standard deviations were lower than 5.3%; the recovery rates were from 89.7% to 107.5%, and the linear correlation was obsenved in a range of 1×10^-6~1×10^-1 g/L, and the linear correlation coefficients were greater than 0.999 0. In the experiment, eight impurities were determined in medical HFC-134a, and the concentrations of the micro-impurities were found to be 1.22 μg/L for HFC-143a, 116.1 μg/L for HCFC-1122, 2.73 μg/L for CFC-114, 3.21 μg/L for HFC-125, 2.80 μg/L for HCFC-124, 4.99 μg/L for HFC-134 and 278.6 μg/L for HCFC-133a, respectively, but the concentration of HCFC-1122a was out of the quantitative limit. The method is simple, fast and applicable to the routine qualitative analysis of medical HFC-134a.
- gas chromatography,
- medical HFC-134a,
- qualitative analysis,
- quantitative analysis
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