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Citation: LI Jing, GONG Mei-Juan, HAN Tao, WANG Bing-Xiang, LU Tian-Hong, GE Cun-Wang, DU Jiang-Yan. Interaction of Indolizine-naphthoquinone Compounds with CT-DNA[J]. Chinese Journal of Applied Chemistry, ;2007, 24(12): 1349-1353. shu

Interaction of Indolizine-naphthoquinone Compounds with CT-DNA

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a Department of Chemistry and Environmental Science, Nanfing Normal University, Nanjing 210097;
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b Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun;
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c School of Chemistry and Chemical Engineering, Nantong University, Nantong

Corresponding author: DU Jiang-Yan,
Received Date: 6 January 2007
Available Online: 10 March 2007
Fund Project: 国家自然科学基金(60571055)资助项目 (60571055)江苏省普通高校自然科学研究计划(06KJB150054) (06KJB150054)

The interactions of four indolizine-naphthoquinone(INQ) compounds with calf thymus DNA(CT-DNA) were studied by means of cyclic voltammetry and UV-Vis absorption spectroscopy techniques.A couple of strong redox peaks were observed in the cyclic voltammograms of the INQ compounds.Upon addition of CT-DNA,both the peak currents and the UV-Vis absorbance of the INQ compounds decreased and the peaks shifted to the positive direction with the increase of the CT-DNA concentration.The experimental results suggest that the interaction of the INQ with the CT-DNA belongs to the intercalative mode.In addition,the intercalative binding between the INQ and the CT-DNA is influenced by the conjugated system in the INQ.With longer conjugation,the π-π stack interaction between the INQ and the CT-DNA bases was strengthened and then the intercalative binding of the INQ with the CT-DNA was also strengthened.
- indolizine-naphthoquinone,
- calf thymus DNA,
- electrochemistry,
- UV-Vis absorption spectroscopy
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