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Citation: CHEN Wei-Hua, LI Wei-Si, LI Zhen-Jiang. One-pot synthesis of α-Amino Phosphonates Under Solvent-free Conditions Catalyzed by Sulfamic Acid[J]. Chinese Journal of Applied Chemistry, ;2008, 25(7): 859-861. shu

One-pot synthesis of α-Amino Phosphonates Under Solvent-free Conditions Catalyzed by Sulfamic Acid

1.
College of Life Science and Pharmacy, Nanjing University of Technology, Nanjng 210009

Corresponding author: LI Zhen-Jiang,
Received Date: 19 June 2007
Available Online: 27 August 2007
Fund Project: 国家"九七三"计划资助项目(2007CB74305) (2007CB74305)

α-Amino phosphonates were one-pot synthesized from carbonyl compound,amines,diethylphosphite with the inexpensive,nontoxic and readily available sulfamic acid as Lewis acid catalyst.The syntheses were carried out under solvent-free conditions at ambient temperature.Seven products were given and the structures of target compounds were confirmed by ¹H NMR.The overall yields of the products were all above 80%.This method was mild,simple,safe and easily manipulated.After the reaction was completed,the catalyst of sulfamic acid could be recovered after simple treatment and could be used for next cycle.
- sulfamic acid,
- α-amino phosphonate,
- diethylphosphite
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