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Citation: DONG Feng-Shou, CAO Qiao, LIU Xin-Gang, ZHENG Yong-Quan, LI Chong-Jiu. Enantiomeric Separation of Simeconazole by HPLC with Amylose Chiral Column[J]. Chinese Journal of Applied Chemistry, ;2008, 25(10): 1237-1239. shu

Enantiomeric Separation of Simeconazole by HPLC with Amylose Chiral Column

1.
a College of Science, China Agricultural University, Beijing 100094;
2.
b Institute of Plant Protection, Chinese Academy of Agricultural Sciences, MOA Key Laboratory of Pesticide Chemistry and Application, Beijing 100094

Corresponding author: DONG Feng-Shou,
Received Date: 20 September 2007
Available Online: 29 November 2007
Fund Project: 国家重点基础研究("九七三"项目)(2002CB410806) ("九七三"项目)(2002CB410806)

Enantiomeric separation of simeconazole was performed by high performance liquid chromatography with the coating-type amylose-tris[(s)-α-methyphenylcarbamate] as the chiral stationary phase(CSP).The chromatographic conditions were optimized by studying the influence of the mobile phase composition including the concentration and type of the alcohol modifier in hexane on enantiomers separation.The data indicated that simeconazole was best separated with the resolutions of 1.39 and 3.75 by 2% iso-propanol or ethanol as the mobile phase respectively,ethanol had a higher separation efficiency than isopropanol.The effect of temperature on chiral separation was investigated,and it was found that lower column temperatures resulted in better separation of simeconazole.
- simeconazole,
- amylose-tris[(s)-α-methyphenylcarbamate],
- chiral separation,
- chiral stationary phase,
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