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Citation: LI Sheng-Fang, HUANG Wei-Dong, LIU Xian-Li, DENG Xiang-Yi. Synthesis,Absorption and Release of BSA of Enzymatically Degradable pH- and Temperature-sensitive Hydrogels[J]. Chinese Journal of Applied Chemistry, ;2008, 25(10): 1225-1228. shu

Synthesis,Absorption and Release of BSA of Enzymatically Degradable pH- and Temperature-sensitive Hydrogels

1.
School of Chemical and Material Engineering, Huangshi Institute of Technology, Huangshi 435003

Corresponding author: LI Sheng-Fang,
Received Date: 19 October 2007
Available Online: 6 January 2008
Fund Project: 黄石理工学院引进人才自然科学基金(07yjz01R)资助项目 (07yjz01R)

The enzymatically degradable poly(N-isopropylacrylamide-co-acrylic acid) hydrogels were prepared with 4,4'-bis(methacryloylamino)azobenzene(BMAAB) as a crosslinker.It was found that the hydrogels exhibited a phase transition temperature between 4℃(refrigerator temperature) and 37℃(human body temperature).Bovine Serum albumin(BSA) as a model drug was loaded into the hydrogels.The loading capability was 144.5 mg BSA/g gel in buffer solution(pH=7.4) at 4℃,while it was 14.8 mg BSA/g gel at 37℃.The hydrogels can be degraded by cecal bacteria and cumulative release may be 100 mg BSA/g gel 4 days after enzymatic degradation of hydrogel in pH=7.4 buffer solution containing cecal bacteria at 37℃.
- hydrogel,
- enzymatic degradation in vitro,
- thermosensitive,
- release
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