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Citation: WANG Zhao-Yang, WANG Yan, SONG Guang-Wei, ZHU Jin-Tao. A Novel Synthesis of L-and D-Fork Glycerinol[J]. Chinese Journal of Applied Chemistry, ;2008, 25(11): 1375-1377. shu

A Novel Synthesis of L-and D-Fork Glycerinol

1.
Department of Chemistry, Zhefiang Sci-Tech University, Hangzhou 310018

Corresponding author: ZHU Jin-Tao,
Received Date: 8 October 2007
Available Online: 7 November 2007

A novel efficient method for preparing L-and D-fork glycerinol is described.Highly enantioenriched(S)-epichlorohydrin and(R)-3-chloro-1,2-propanediol were prepared from the reaction of dynamic hydrolysis resolution of racemic epichlorohydrin by chiral Salen-CoⅢ complex.(S)-epichlorohydrin was used to afford L-fork glycerinol by hydrolysis,condensation,displacement,and alcoholysis.The overall yield was 59.4%.D-fork glycerinol was prepared from(R)-3-chloro-1,2-propanediol,and the overall yield was 62.5%.The chemical structures of the target compounds were confirmed by IR,¹H NMR and MS.
- Salen-CoⅢ,
- racemic epichlorohydrin,
- levo,
- dextral,
- fork glycerinol,
- synthesis
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