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Citation: GAO Li-Ping, ZHANG Guo-Qing. Enantiomer Seperation of Norepinephrine Bitartrate with Chiral HPLC method[J]. Chinese Journal of Applied Chemistry, ;2008, 25(11): 1366-1368. shu

Enantiomer Seperation of Norepinephrine Bitartrate with Chiral HPLC method

GAO Li-Ping ^a,, ,
ZHANG Guo-Qing ^b

1.
a Department of Applied Chemistry, Zhejiang Sci-Tech University, Hangzhou 310017;
2.
b MOE Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Zhejiang Sci-Tech University, Hangzhou 310017

Corresponding author: GAO Li-Ping,
Received Date: 20 October 2007
Available Online: 6 January 2008
Fund Project: 浙江省教育厅课题资助项目(20060576) (20060576)

An isocratic chiral HPLC method was developed for the separation of Norepinephrine Bitartrate enantiomers.The enantioseperation was carried out on a Chiralpak AD-H column with V(n-hexane):V(ethanol):V(ethanolamine)=80:20:0.2 as the mobile phase at UV 280 nm.The method is precise,linear,sensitive and accurate for quantification or ee(%) determination.The relationship between specific rotation and enantiomeric excess purity was studied for Norepinephrine Bitartrate products.
- Norepinephrine Bitartrate,
- enantiomer,
- chiral HPLC,
- chiral seperation
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