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Citation: LIU Hong-Xia, WANG Zi-Min. Synthesis of Isosorbide-2-monoacetate in Ionic Liquid[J]. Chinese Journal of Applied Chemistry, ;2008, 25(12): 1502-1504. shu

Synthesis of Isosorbide-2-monoacetate in Ionic Liquid

LIU Hong-Xia ^a,, ,
WANG Zi-Min ^b

1.
College of Chemistry and Chemical Engineering Qiqihar University, Qiqihar 161006;
2.
b Ocean University of China Lantai Pharmacy, Qingdao

Corresponding author: LIU Hong-Xia,
Received Date: 19 November 2007
Available Online: 28 January 2008
Fund Project: 齐齐哈尔市科技局重点资助项目(GG06-18) (GG06-18)黑龙江省教育厅科学技术研究项目资助(11511442) (11511442)

Isosorbide-5-mononitrate is a new long-lasting nitrate medicine for angina pectoris.Ionic liquid was used in the synthesis of the intermediate of isosorbide-5-mononitrate.Isosorbide was purified by extraction of the crude product with ionic liquid 1-butyl-3-methyl imidazole hexafluorophosphate instead of high vacuum distillation.Isosorbide-2-monoacetate was then synthesized by reacting the purified isosorbide with acetic anhydride in acidic ionic liquid N-methylimidazole hydrosulfate.The structures of products were characterized by means of IR techniques.The yields of isosorbide and isosorbide-2-monoacetate were 80% and 86% respectively.
- isosorbide-mononitrate,
- ionic liquid,
- synthesis
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