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Citation: MENG Pin-Jia, WANG Yan-Yan, ZHU Dan. Small-volume Liquid Extraction of Amphetamines from Bio-samples and GC/MS Analysis[J]. Chinese Journal of Applied Chemistry, ;2008, 25(12): 1448-1454. shu

Small-volume Liquid Extraction of Amphetamines from Bio-samples and GC/MS Analysis

1.
Forensic Science Department, Chinese People's Public Security University, Beijing 100038

Corresponding author: MENG Pin-Jia,
Received Date: 20 November 2007
Available Online: 29 January 2008
Fund Project: 北京教育委员会共建项目建设计划(SYS1004100436) (SYS1004100436)

The presented study is focused on the investigation of influence factors and mechanism of small-volume liquid extraction of four amphetamines,named amphetamine(AM),methamphetamine(MAM),3,4-methylenedioxyamphetamine(MDA) and 3,4-methylenemethamphtamine(MDMA) in biological samples.The extraction efficiencies between regular volume and small volume extraction methods were compared;some influence factors for small-volume liquid extraction such as the type and volume of organic solvent,concentration of target analytes in aqueous phase were examined,and the mechanism was studied preliminarily.It was shown that small-volume liquid extraction has a certain effect on the enrichment of analytes,the smaller the volume was,and also the lower the analytes concentration in aqueous solution was,the greater the enrichment gained.It could be deduced that organic film between organic and aqueous phases played an important role in the enrichment.Some biological specimens such as saliva and hair were extracted by means of the method.The organic phase was directly injected into GC for analysis,or transferred into another vial for derivatization after extraction.The LOD for these amphetamines was 5×1^-8 g/mL in saliva with GC/MS-SIM without derivatization,and 5×10^-11 g/mg in hair after MBTFA derivatization.The method validation data demonstrate that all parameters such as linearity,repeatability,relative standard variation and accuracy can meet the requirement for the drug analysis.The extraction procedure is simple,sensitive,economic and time-saving,and can be used for the analysis of the drugs in biological specimens.
- small volume liquid extraction,
- amphetamines,
- saliva,
- hair,
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