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Citation: FENG Su-Linga, PAN Zi-Hong, FAN Jing. Resonance Light Scattering Technique for Determination of Trace Promethazine Hydrochloride in the Presence of Eosin B[J]. Chinese Journal of Applied Chemistry, ;2008, 25(12): 1444-1447. shu

Resonance Light Scattering Technique for Determination of Trace Promethazine Hydrochloride in the Presence of Eosin B

1.
a College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007;
2.
b Department of Chemistry, Pingdingshan College, Pingdingshan

Corresponding author: FENG Su-Linga,
Received Date: 2 December 2007
Available Online: 9 April 2008
Fund Project: 河南省自然科学基金资助项目(0511021200) (0511021200)新乡市科技发展项目(07G052) (07G052)

A novel,simple and selective method was developed for the determination of promethazine hydrochloride with the resonance light scattering technique.The method was based on the enhancement effect of promethazine hydrochloride on the weak resonance light scattering of eosine B in a pH=3.50 Walpole buffer solution with the maximum light scattering peak at 363 nm.The enhanced RLS intensity was proportional to the concentration of promethazine hydrochloride in a range of 7.5×10^-8~4.5×10^-6 g/mL with a detection limit of 1.8×10^-8 g/mL.This method has been applied successfully to the determination of promethazine hydrochloride in tablets,injection and spiked biological fluid samples.
- promethazine hydrochloride,
- eosine B,
- resonance light scattering
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