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Citation: WANG Cheng-Xue, CHU Zhan-Fang. Synthesis of Rutaecarpine and Quinazolone Compounds[J]. Chinese Journal of Applied Chemistry, ;2008, 25(12): 1439-1443. shu

Synthesis of Rutaecarpine and Quinazolone Compounds

WANG Cheng-Xue ^, ,
CHU Zhan-Fang

1.
Changchun University of Technology, Changchun 130012

Corresponding author: WANG Cheng-Xue,
Received Date: 9 November 2007
Available Online: 6 January 2008
Fund Project: 吉林省科技厅计划资助项目(19980564) (19980564)

2-(3-Indoly)ethyamine and 2-aminobenzoic acid were used as the starting material and iminoketene was used as the key intermediate to react with 3,4-dihydro-β-carboline or 3,4-dihydroisoquinoline.The reaction afforded rutaecarpine.The reaction is simple and yield is high.Quinazolone compounds can be easily synthesized by the same method with 2-(3,4-diethoxyphenyl)ethylamine as the starting material.The paper thus gives a method for the synthesis of pharmacological active rutaecarpine and quinazolone in industry.The obtained compounds were characterized by ESI-MS,¹H NMR,¹³C NMR.
- rutecarpine,
- quinazolone,
- Diels-Alder-type
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