Citation: N.C. Desai, N.R. Shihory, G.M. Kotadiya. Facile synthesis of benzimidazole bearing 2-pyridone derivatives as potential antimicrobial agents[J]. Chinese Chemical Letters, ;2014, 25(2): 305-307. shu

Facile synthesis of benzimidazole bearing 2-pyridone derivatives as potential antimicrobial agents

1.
Division of Medicinal Chemistry, Department of Chemistry (UGC NON-SAP & DST-FIST Sponsored), M.K. Bhavnagar University, Bhavnagar 364 002, India

Corresponding author: N.C. Desai,
Received Date: 29 July 2013
Available Online: 4 November 2013

A series of benzimidazole bearing 2-pyridones 5a-k were synthesized and assessed in vitro for their activity as antimicrobial agents using the conventional broth dilution method. The results of the antimicrobial study revealed that compounds 5b, 5c, 5j and 5k exhibited substantial antibacterial activity while compound 5d emerged as amore potent antifungal agent compared to the standard drugs chloramphenicol and ketoconazole, respectively. It was observed that the presence of inductively electron withdrawing groups remarkably enhance the antibacterial activity of the newly synthesized compounds. Cytotoxicity studies suggested that none of the tested compounds exhibited any significant cytotoxic effects.
- Benzimidazole,
- 2-Pyridone,
- Antimicrobial activity,
- Cytotoxicity
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沈阳化工大学材料科学与工程学院沈阳 110142