Citation: Rong-Hui Lai, Ping-Jiang Dong, Yong-Li Wang, Jian-Bin Luo. Redispersible and stable amorphous calcium phosphate nanoparticles functionalized by an organic bisphosphate[J]. Chinese Chemical Letters, ;2014, 25(2): 295-298. shu

Redispersible and stable amorphous calcium phosphate nanoparticles functionalized by an organic bisphosphate

1.
Department of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041, China

Corresponding author: Jian-Bin Luo,
Received Date: 23 September 2013
Available Online: 25 October 2013
Fund Project: We acknowledge the financial supports from the Natural Science Foundation of China (No. 50973069) (No. 50973069) the project of Postgraduate Degree Construction, Southwest University for Nationalities (No. 2013XWD-S0703). (No. 2013XWD-S0703)

Althoughmuch effort has been focused on the preparation of stable amorphous calciumphosphate (ACP) nanoparticles in aqueous solution, the redispersibility and long-term stability of ACP nanoparticles in aqueous solution remains an unresolved problem. In this work, stable colloidal ACPs were prepared by using an organic bisphosphonate (BP) as a sterically hindered agent in aqueous solution. The harvested calcium phosphate nanoparticles were characterized by inductively coupled plasma atomic emission spectrometry (ICP-AES), Fourier transform infrared (FTIR), X-ray diffraction (XRD), dynamic light scattering (DLS) and transmission electron microscopy (TEM). ICP-AES, FTIR and XRD results suggested the particles were ACP. DLS and TEM results indicated that the size of the ACP nanoparticles were in the range of 60 nm with a spherical morphology. The resulting calciumphosphate nanoparticles retained its amorphous nature in aqueous solution for at least 6 months at room temperature due to the stabilizing effect of the organic bisphosphonate. Moreover, the surface of the ACP nanoparticles adsorbed with the organic bisphosphate used showed good redispersibility and high colloid stability both in organic and aqueous solutions.
- Amorphous calcium phosphate,
- Bisphosphate,
- Nanoparticle,
- Redispersibility,
- Stability
1. [1]
  [1] H.A. Lowenstam, S. Weiner, Transformation of amorphous calcium phosphate to crystalline dahillite in the radular teeth of chitons, Science 227 (1985) 51-53.
2. [2]
  [2] I.M. Weiss, N. Tuross, L. Addadi, S. Weiner, Mollusc larval shell formation: amorphous calcium carbonate is a precursor phase for aragonite, J. Exp. Zool. 293 (2002) 478-491.
3. [3]
  [3] E. Beniash, J. Aizenberg, L. Addadi, S. Weiner, Amorphous calcium carbonate transforms into calcite during sea urchin larval spicule growth, Proc. R. Soc. B: Biol. Sci. 264 (1997) 461-465.
4. [4]
  [4] M. Nagano, T. Nakamura, T. Kokubo, M. Tanahashi, M. Ogawa, Differences of bone bonding ability and degradation behaviour in vivo between amorphous calcium phosphate and highly crystalline hydroxyapatite coating, Biomaterials 17 (1996) 1771-1777.
5. [5]
  [5] A.S. Posner, F. Betts, Synthetic amorphous calcium phosphate and its relation to bone mineral structure, Acc. Chem. Res. 8 (1975) 273-281.
6. [6]
  [6] T. Kanazawa, T. Umegaki, N. Uchiyama, Thermal crystallisation of amorphous calcium phosphate to a-tricalcium phosphate, J. Chem. Technol. Biotechnol. 32 (1982) 399-406.
7. [7]
  [7] E.T. Hwang, R. Tatavarty, J.Y. Chung, M.B. Gu, New functional amorphous calcium phosphate nanocomposites by enzyme-assisted biomineralization, ACS Appl. Mater. Interfaces 5 (2013) 532-537.
8. [8]
  [8] J. Li, Y.C. Chen, Y.C. Tseng, S. Mozumdar, L. Huang, Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery, J. Control. Release 142 (2010) 416-421.
9. [9]
  [9] A. Oyane, H. Araki, Y. Sogo, A. Ito, H. Tsurushima, Spontaneous assembly of DNA- amorphous calcium phosphate nanocomposite spheres for surface-mediated gene transfer, CrystEngComm^-15 (2013) 4994-4997.
10. [10]
  [10] M. Epple, K. Ganesan, R. Heumann, et al., Application of calcium phosphate nanoparticles in biomedicine, J. Mater. Chem. 20 (2010) 18-23.
11. [11]
  [11] C. Qi, Y.J. Zhu, F. Chen, Fructose 1,6-bisphosphate trisodium salt as a new phosphorus source for the rapid microwave synthesis of porous calcium-phosphate microspheres and their application in drug delivery, Chem. Asian J. 8 (2013) 88-94.
12. [12]
  [12] P. Keblinski, S.R. Phillpot, D. Wolf, H. Gleiter, Thermodynamic criterion for the stability of amorphous intergranular films in covalent materials, Phys. Rev. Lett. 77 (1996) 2965-2968.
13. [13]
  [13] J. Christoffersen, M.R. Christoffersen, W. Kibalczyc, F.A. Andersen, A contribution to the understanding of the formation of calcium phosphates, J. Cryst. Growth 94 (1989) 767-777.
14. [14]
  [14] Y.B. Li, T. Wiliana, K.C. Tam, Synthesis of amorphous calcium phosphate using various types of cyclodextrins, Mater. Res. Bull. 42 (2007) 820-827.
15. [15]
  [15] C.F. Qiu, X.F. Xiao, R.F. Liu, Biomimetic synthesis of spherical nano-hydroxyapatite in the presence of polyethylene glycol, Ceram. Int. 34 (2008) 1747-1751.
16. [16]
  [16] R. Li, G.M. Chen, X.L. Ma, et al., Mineralization of HA crystals regulated by terephthaloyl chloride-modified silk fibroin films, Chin. Chem. Lett. 22 (2011) 1107-1110.
17. [17]
  [17] M.G. Ma, Y.J. Zhu, J. Chang, Monetite formed in mixed solvents of water and ethylene glycol and its transformation to hydroxyapatite, J. Phys. Chem. B 110 (2006) 14226-14230.
18. [18]
  [18] P. Zhang, Z.Y. Yang, S.X. Qiu, et al., Synthesis and characterization of poly (ethylene glycol)/hydroxyapatite hybrid nanomaterials, Chem. J. Chin. Univ. 33 (2012) 22-25.
19. [19]
  [19] G.A. Rodan, H.A. Fleisch, Bisphosphonates: mechanisms of action, J. Clin. Invest. 97 (1996) 2692-2696.
20. [20]
  [20] S. Boissier, M. Ferreras, O. Peyruchaud, et al., Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases, Cancer Res. 60 (2000) 2949-2954.
21. [21]
  [21] M. Naves, L. Gano, N. Pereira, et al., Synthesis, characterization and biodistribution of bisphosphonates Sm-153 complexes, correlation with molecular modeling interaction studies, Nucl. Med. Biol. 29 (2002) 329-338.
22. [22]
  [22] S. Boissier, S. Magnetto, L. Frappart, et al., Bisphosphonates inhibit prostate and breast carcinoma cell adhesion to unmineralized and mineralized bone extracellular matrices, Cancer Res. 57 (1997) 3890-3894.
23. [23]
  [23] P. Kafarski, B. Lejczak, Aminophosphonic acids of potential medical importance, Curr. Med. Chem. Anti Cancer Agents 1 (2001) 301-312.
24. [24]
  [24] A. Zieba, G. Sethuraman, F. Perez, G.H. Nancollas, D. Cameron, Influence of organic phosphonates on hydroxyapatite crystal growth kinetics, Langmuir 12 (1996) 2853-2858.
25. [25]
  [25] D. Villemin, B. Moreau, A. Elbilali, et al., Green synthesis of poly(aminomethylenephosphonic) acids, Phosphorus Sulfur Silicon Relat. Elem. 185 (2010) 2511-2519.
26. [26]
  [26] L. Addadi, S. Raz, S. Weiner, Taking advantage of disorder: amorphous calcium carbonate and its roles in biomineralization, Adv. Mater. 15 (2003) 959-970.
27. [27]
  [27] X.Y. Zhou, Y.R. Jiang, C.C. Li, X.Y. Xie, Synthesis of poly(ethylene glycol)-functionalized hydroxyapatite organic colloid intended for nanocomposites, Chin. Chem. Lett. 24 (2013) 647-650.
28. [28]
  [28] B. Khorsand, G. Lapointe, C. Brett, J.K. Oh, Intracellular drug delivery nanocarriers of glutathione-responsive degradable block copolymers having pendant disulfide linkages, Biomacromolecules 14 (2013) 2103-2111.
29. [29]
  [29] Y.R. Cai, H.H. Pan, X.R. Xu, et al., Ultrasonic controlled morphology transformation of hollow calcium phosphate nanospheres: a smart and biocompatible drug release system, Adv. Mater. 19 (2007) 3081-3083.
30. [30]
  [30] K.W. Wang, Y.J. Zhu, X.Y. Chen, et al., Flower-like hierarchically nanostructured hydroxyapatite hollow spheres: facile preparation and application in anticancer drug cellular deliver, Chem. Asian J. 5 (2010) 2477-2482.
31. [31]
  [31] M. Uota, H. Arakawa, N. Kitamura, et al., Synthesis of high surface area hydroxyapatite nanoparticles by mixed surfactant-mediated approach, Langmuir 21 (2005) 4724-4728.
1. [1]
  Jingyuan Yang , Xinyu Tian , Liuzhong Yuan , Yu Liu , Yue Wang , Chuandong Dou . Enhancing stability of diradical polycyclic hydrocarbons via P=O-attaching. Chinese Chemical Letters, 2024, 35(8): 109745-. doi: 10.1016/j.cclet.2024.109745
2. [2]
  Ting Wang , Xin Yu , Yaqiang Xie . Unlocking stability: Preserving activity of biomimetic catalysts with covalent organic framework cladding. Chinese Chemical Letters, 2024, 35(6): 109320-. doi: 10.1016/j.cclet.2023.109320
3. [3]
  Qiyan Wu , Ruixin Zhou , Zhangyi Yao , Tanyuan Wang , Qing Li . Effective approaches for enhancing the stability of ruthenium-based electrocatalysts towards acidic oxygen evolution reaction. Chinese Chemical Letters, 2024, 35(10): 109416-. doi: 10.1016/j.cclet.2023.109416
4. [4]
  Xingang Kong , Yabei Su , Cuijuan Xing , Weijie Cheng , Jianfeng Huang , Lifeng Zhang , Haibo Ouyang , Qi Feng . Facile synthesis of porous TiO₂/SnO₂ nanocomposite as lithium ion battery anode with enhanced cycling stability via nanoconfinement effect. Chinese Chemical Letters, 2024, 35(11): 109428-. doi: 10.1016/j.cclet.2023.109428
5. [5]
  Xinpin Pan , Yongjian Cui , Zhe Wang , Bowen Li , Hailong Wang , Jian Hao , Feng Li , Jing Li . Robust chemo-mechanical stability of additives-free SiO₂ anode realized by honeycomb nanolattice for high performance Li-ion batteries. Chinese Chemical Letters, 2024, 35(10): 109567-. doi: 10.1016/j.cclet.2024.109567
6. [6]
  Chengde Wang , Liping Huang , Shanshan Wang , Lihao Wu , Yi Wang , Jun Dong . A distinction of gliomas at cellular and tissue level by surface-enhanced Raman scattering spectroscopy. Chinese Chemical Letters, 2024, 35(5): 109383-. doi: 10.1016/j.cclet.2023.109383
7. [7]
  Hongmei Yu , Baoxi Zhang , Meiju Liu , Cheng Xing , Guorong He , Li Zhang , Ningbo Gong , Yang Lu , Guanhua Du . Theoretical and experimental cocrystal screening of temozolomide with a series of phenolic acids, promising cocrystal coformers. Chinese Chemical Letters, 2024, 35(5): 109032-. doi: 10.1016/j.cclet.2023.109032
8. [8]
  Wenxiang Ma , Xinyu He , Tianyi Chen , De-Li Ma , Hongzheng Chen , Chang-Zhi Li . Near-infrared non-fused electron acceptors for efficient organic photovoltaics. Chinese Chemical Letters, 2024, 35(4): 109099-. doi: 10.1016/j.cclet.2023.109099
9. [9]
  Liang Ming , Dan Liu , Qiyue Luo , Chaochao Wei , Chen Liu , Ziling Jiang , Zhongkai Wu , Lin Li , Long Zhang , Shijie Cheng , Chuang Yu . Si-doped Li₆PS₅I with enhanced conductivity enables superior performance for all-solid-state lithium batteries. Chinese Chemical Letters, 2024, 35(10): 109387-. doi: 10.1016/j.cclet.2023.109387
10. [10]
  Chenghao Ge , Peng Wang , Pei Yuan , Tai Wu , Rongjun Zhao , Rong Huang , Lin Xie , Yong Hua . Tuning hot carrier transfer dynamics by perovskite surface modification. Chinese Chemical Letters, 2024, 35(10): 109352-. doi: 10.1016/j.cclet.2023.109352
11. [11]
  Rui Liu , Yue Yu , Lu Deng , Maoxia Xu , Haorong Ren , Wenjie Luo , Xudong Cai , Zhenyu Li , Jingyu Chen , Hua Yu . The synergistic effect of A-site cation engineering and phase regulation enables efficient and stable Ruddlesden-Popper perovskite solar cells. Chinese Chemical Letters, 2024, 35(12): 109545-. doi: 10.1016/j.cclet.2024.109545
12. [12]
  Yan-Kai Zhang , Yong-Zheng Zhang , Chun-Xiao Jia , Fang Wang , Xiuling Zhang , Yuhang Wu , Zhongmin Liu , Hui Hu , Da-Shuai Zhang , Longlong Geng , Jing Xu , Hongliang Huang . A stable Zn-MOF with anthracene-based linker for Cr(VI) photocatalytic reduction under sunlight irradiation. Chinese Chemical Letters, 2024, 35(12): 109756-. doi: 10.1016/j.cclet.2024.109756
13. [13]
  Jinqiang Gao , Haifeng Yuan , Xinjuan Du , Feng Dong , Yu Zhou , Shengnan Na , Yanpeng Chen , Mingyu Hu , Mei Hong , Shihe Yang . Methanol steam mediated corrosion engineering towards high-entropy NiFe layered double hydroxide for ultra-stable oxygen evolution. Chinese Chemical Letters, 2025, 36(1): 110232-. doi: 10.1016/j.cclet.2024.110232
14. [14]
  Rongjun Zhao , Tai Wu , Yong Hua , Yude Wang . Improving performance of perovskite solar cells enabled by defects passivation and carrier transport dynamics regulation via organic additive. Chinese Chemical Letters, 2025, 36(2): 109587-. doi: 10.1016/j.cclet.2024.109587
15. [15]
  Guilong Li , Wenbo Ma , Jialing Zhou , Caiqin Wu , Chenling Yao , Huan Zeng , Jian Wang . A composite hydrogel with porous and homogeneous structure for efficient osmotic energy conversion. Chinese Chemical Letters, 2025, 36(2): 110449-. doi: 10.1016/j.cclet.2024.110449
16. [16]
  Zijian Jiang , Yuang Liu , Yijian Zong , Yong Fan , Wanchun Zhu , Yupeng Guo . Preparation of Nano Zinc Oxide by Microemulsion Method and Study on Its Photocatalytic Activity. University Chemistry, 2024, 39(5): 266-273. doi: 10.3866/PKU.DXHX202311101
17. [17]
  Jiaxi Xu , Yuan Ma . Influence of Hyperconjugation on the Stability and Stable Conformation of Ethane, Hydrazine, and Hydrogen Peroxide. University Chemistry, 2024, 39(11): 374-377. doi: 10.3866/PKU.DXHX202402049
18. [18]
  Hailian Tang , Siyuan Chen , Qiaoyun Liu , Guoyi Bai , Botao Qiao , Fei Liu . Stabilized Rh/hydroxyapatite Catalyst for Furfuryl Alcohol Hydrogenation: Application of Oxidative Strong Metal-Support Interactions in Reducing Conditions. Acta Physico-Chimica Sinica, 2025, 41(4): 100036-. doi: 10.3866/PKU.WHXB202408004
19. [19]
  Hongxia Li , Xiyang Wang , Du Qiao , Jiahao Li , Weiping Zhu , Honglin Li . Mechanism of nanoparticle aggregation in gas-liquid microfluidic mixing. Chinese Chemical Letters, 2024, 35(4): 108747-. doi: 10.1016/j.cclet.2023.108747
20. [20]
  Yixin Zhang , Ting Wang , Jixiang Zhang , Pengyu Lu , Neng Shi , Liqiang Zhang , Weiran Zhu , Nongyue He . Formation mechanism for stable system of nanoparticle/protein corona and phospholipid membrane. Chinese Chemical Letters, 2024, 35(4): 108619-. doi: 10.1016/j.cclet.2023.108619

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(696)
HTML views(10)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142