Citation: Shi-Ping Zhu, Wen-Ya Wang, Kun Fang, Zheng-Gang Li, Guo-Qiang Dong, Zhen-Yuan Miao, Jian-Zhong Yao, Wan-Nian Zhang, Chun-Quan Sheng. Design, synthesis and antifungal activity of carbazole derivatives[J]. Chinese Chemical Letters, ;2014, 25(2): 229-233. shu

Design, synthesis and antifungal activity of carbazole derivatives

1.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Corresponding author: Wan-Nian Zhang, Chun-Quan Sheng,
Received Date: 29 August 2013
Available Online: 9 October 2013
Fund Project: This work was supported in part by the National Natural Science Foundation of China (No. 81222044) (No. 81222044) the 863 Hi-Tech Program of China (No. 2012AA020302) (No. 2012AA020302) Shanghai Rising-Star Program (No. 12QH1402600) (No. 12QH1402600)

The incidence of invasive fungal infections is increasing rapidly. Clinically available antifungal agents suffer from limited efficacy and severe resistance. There is an urgent need to discover antifungal lead compounds with novel chemical scaffold. On the basis of our previously identified tetrahydrocarbazole antifungal leads, the structure-activity relationship was further explored by modifying the scaffold and the side chains. Several targeted compounds showed potent activity against Candida species. Particularly, compound 13i showed better antifungal activity than the lead compound, which can be used as a good starting point for further optimization.
- Carbazole,
- Antifungal activity,
- Structure-activity relationship
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沈阳化工大学材料科学与工程学院沈阳 110142