Citation: Yue-Dong Li, Wu-Tao Mao, Zhi-Jin Fan, Juan-Juan Li, Zhen Fang, Xiao-Tian Ji, Xue-Wen Hua, Guang-Ning Zong, Feng-Yun Li, Chao-Lun Liu, Jian-Hua Yu. Synthesis and biological evaluation of novel 1,2,4-triazole containing 1,2,3-thiadiazole derivatives[J]. Chinese Chemical Letters, ;2013, 24(12): 1134-1136. shu

Synthesis and biological evaluation of novel 1,2,4-triazole containing 1,2,3-thiadiazole derivatives

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a State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China;
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b Division of Hematology, College of Medicine and School of Public Health, The Ohio State University, Columbus, OH 43210, United States

Corresponding author: Zhi-Jin Fan, Jian-Hua Yu,
Received Date: 3 May 2013
Available Online: 4 June 2013

A series of novel 1,2,4-triazoles containing 1,2,3-thiadiazole derivatives were designed and synthesized. Their structures were confirmed by melting points, IR, ¹H NMR, and elemental analysis and ESI-MS or HRMS. Preliminary bioassays indicated that these compounds exhibited very good insecticidal activity against Aphis laburni at 100 mg/mL, with mortality no less than 95%. Compounds 6a, 6c, 6f, 6l showed higher curative activity against TMV and compound 6h showed a higher induction effects against TMV in vivo at 100 μg/mL. Collectively, our data demonstrate a new strategy for control of insects and viruses.
- 1,2,3-Thiadiazole,
- 1,2,4-Triazole,
- Insecticidal activity,
- Anti-TMV activity
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沈阳化工大学材料科学与工程学院沈阳 110142