Citation: Can-Ling Cheng, Zhong-Zhao Wang, Ping-Lin Li, Xing-Wang Zhang, Rong-Cui Wu, Hong-Yan Zhu, Xu-Li Tang, Guo-Qiang Li. Tetracyclic triterpenoids isolated from semi-mangrove plant Hibiscus tiliaceus[J]. Chinese Chemical Letters, ;2013, 24(12): 1080-1082. shu

Tetracyclic triterpenoids isolated from semi-mangrove plant Hibiscus tiliaceus

1.
a Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China;
2.
b College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, China

Corresponding author: Guo-Qiang Li,
Received Date: 24 April 2013
Available Online: 21 June 2013
Fund Project: This work was supported by the Key International Cooperation Project of CMST (No. 2008DFA31040) (No. 2008DFA31040)the Special Funds for Young Teachers of Ocean University of China (No. 841113070). (No. 841113070)

A continuing phytochemical study on the semi-mangrove plant Hibiscus tiliaceus yielded two new tetracyclic triterpenoids (3β,24S)-19(10→9)-abeo-8α,9β,10α-eupha-5,25(26)-dien-3,24-diol (tiliacol A, 1), and (3β,23Z)-19(10→9)-abeo-8α,9β,10α-tircalla-5,23-dien-3,25-diol (tiliacol B, 3), together with one known analog (2). Their structures were elucidated on the basis of extensive spectral analyses (MS, IR, 1D NMR and 2D NMR) and comparison with literature compounds. Compound 12 showed potent cytotoxicity against both P388 and HeLa cells with IC₅₀ values of 11.2 μmol/L and 11.5 μmol/L, respectively.
- Semi-mangrove,
- Hibiscus tiliaceus (Malvaceae),
- Triterpenoid,
- Cytotoxicity
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