Citation: Qing-Shan Du, Yan-Xia Shi, Peng-Fei Li, Zhen-Jiang Zhao, Wei-Ping Zhu, Xu-Hong Qian, Bao-Ju Li, Yu-Fang Xu. Novel plant activators with thieno[2,3-d]-1,2,3-thiadiazole-6-carboxylate scaffold： Synthesis and bioactivity[J]. Chinese Chemical Letters, ;2013, 24(11): 967-969. shu

Novel plant activators with thieno[2,3-d]-1,2,3-thiadiazole-6-carboxylate scaffold： Synthesis and bioactivity

1.
a Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China;
2.
b Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, China

Corresponding author: Bao-Ju Li, Yu-Fang Xu,
Received Date: 17 April 2013
Available Online: 9 June 2013

The 1,2,3-thiadiazole-carboxylate moiety was reported to be an important pharmacophore of plant activators. In this study, a series of novel plant activators based on thieno[2,3-d]-1,2,3-thiadiazole-6-carboxylate were designed and synthesized and their biological activity as plant activators was studied. The structures of the novel compounds were identified by ¹H NMR, ¹⁹F NMR and HRMS. The in vivo bioassay showed that these novel compounds had good efficacy against seven plant diseases. Especially, compounds 1a and 1c were more potent than the commercialized plant activator BTH. Almost no fungicidal activity was observed for the active compounds in the in vivo assay, which matched the requirements as plant activators.
- Thieno[2,3-d]-1,2,3-thiadiazole-6-carboxylate derivatives,
- Plant activator,
- Systemic acquired resistance
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1.
沈阳化工大学材料科学与工程学院沈阳 110142