Citation: Ratchanok Pingaew, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul. Tungstophosphoric acid catalyzed synthesis of N-sulfonyl-1,2,3,4-tetrahydroisoquinoline analogs[J]. Chinese Chemical Letters, ;2013, 24(10): 941-944. shu

Tungstophosphoric acid catalyzed synthesis of N-sulfonyl-1,2,3,4-tetrahydroisoquinoline analogs

1.
a Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand;
2.
b Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand;
3.
c Chulabhorn Research Institute, Bangkok 10210, Thailand;
4.
d Chulabhorn Graduate Institute and Center of Excellence on Environmental Health and Toxicology (EHT), Bangkok 10210, Thailand;
5.
e Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand

Corresponding author: Ratchanok Pingaew,
Received Date: 28 March 2013
Available Online: 8 June 2013
Fund Project:

An operationally simple and eco-friendly protocol has been developed for the synthesis of N-sulfonyl-1,2,3,4-tetrahydroisoquinolines 3 using the modified Pictet-Spengler reaction of N-sulfonylphenylethylamines 1 and various aldehydes 2 in the presence of tungstophosphoric acid hydrate.
- Pictet-Spengler reaction,
- Isoquinoline,
- Heteropoly acid,
- Sulfonamide
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