Citation: Yu-Ji Pu, Hui Yuan, Ming Yang, Bin He, Zhong-Wei Gu. Synthesis of peptide dendrimers with polyhedral oligomeric silsesquioxane cores via click chemistry[J]. Chinese Chemical Letters, ;2013, 24(10): 917-920. shu

Synthesis of peptide dendrimers with polyhedral oligomeric silsesquioxane cores via click chemistry

1.
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China

Corresponding author: Zhong-Wei Gu,
Received Date: 24 April 2013
Available Online: 4 June 2013
Fund Project: This researchworkwas supported by the National Basic Research Program of China (National 973 program, No. 2011CB606206) (National 973 program, No. 2011CB606206) National Science Foundation of China (NSFC, Nos. 31170921, 51133004) (NSFC, Nos. 31170921, 51133004) the National Science Foundation for Excellent Young Scholars (No. 51222304) (No. 51222304)

Inorganic polyhedral oligomeric silsesquioxane (POSS) was used as the core for the synthesis of poly(Llysine) peptide dendrimer via copper-catalyzed azide-alkyne click chemistry. The inorganic/organic composite dendrimer was characterized by MS, ¹H NMR, FTIR, GPC and DLS.
- Peptide dendrimer,
- Polyhedral oligomeric silsesquioxane,
- Click chemistry
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沈阳化工大学材料科学与工程学院沈阳 110142