Citation: Cheng-Liang Feng, Shu-Guang Zhang, Jun-Qing Chen, Jin Cai, Min Ji. First total synthesis of isoquinolinone alkaloid marinamide and its methyl ester[J]. Chinese Chemical Letters, ;2013, 24(8): 767-769. shu

First total synthesis of isoquinolinone alkaloid marinamide and its methyl ester

1.
Institute of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, China

Corresponding author: Min Ji,
Received Date: 7 March 2013
Available Online: 18 April 2013

The first total synthesis of isoquinolinone alkaloid marinamide 1 and its methyl ester 2 was described. The key steps involved a regioselective Friedel-Crafts reaction of 1-benzyl-1H-pyrrole to form the intermediate 8.
- Marinamide,
- Methyl ester of marinamide,
- Isoquinolinone alkaloid,
- Total synthesis
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