Citation: Xue Li, Cheng-Hua Xu, Chuan-Qi Liu, Yu Chen, Jian-Ying Liu. Synthesis of pyrazinyl compounds from glycerol and 1,2-propanediamine over Cu-TiO₂ catalysts supported on γ-Al₂O₃[J]. Chinese Chemical Letters, ;2013, 24(8): 751-754. shu

Synthesis of pyrazinyl compounds from glycerol and 1,2-propanediamine over Cu-TiO₂ catalysts supported on γ-Al₂O₃

Xue Li ^a ,
Cheng-Hua Xu ^a,, ,
Chuan-Qi Liu ^a,b ,
Yu Chen ^a ,
Jian-Ying Liu ^a

1.
a Air Environmental Modeling and Pollution Controlling Key Laboratory of Sichuan Higher Education Institutes, Chengdu University of Information Technology, Chengdu 610225, China;
2.
b College of Optoelectronic Technology, Chengdu University of Information Technology, Chengdu 610225, China

Corresponding author: Cheng-Hua Xu,
Received Date: 26 February 2013
Available Online: 3 April 2013

Cu-TiO₂ catalysts supported on γ-Al₂O₃ are prepared and used in glycerol cyclization with 1,2-propanediamine to produce pyrazinyl compounds including 6-hydroxymethyl-2-methylpyrazine, 5-hydroxymethyl-2-methylpyrazine, 2,6-dimethylpyrazine and 2,5-dimethylpyrazine in a fixed-bed system. It is found that glycerol cylclization with 1,2-propanediamine gave a high total yield of pyrazinyl compounds (>80%) over Cu-TiO₂/γ-Al₂O₃ catalyst, and cyclization was through the reactions between activated 1,2-propanediamine and the intermediates from glycerol dehydration and oxidation. In addition, the regioselectivity of the pyrazinyl compounds was mainly controlled by the steric hindrance of the substrates during the cyclization process.
- Catalytic cyclization,
- Glycerol,
- Alkyl-substituted pyrazines,
- Steric effect
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Synthesis of pyrazinyl compounds from glycerol and 1,2-propanediamine over Cu-TiO2 catalysts supported on γ-Al2O3

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Synthesis of pyrazinyl compounds from glycerol and 1,2-propanediamine over Cu-TiO₂ catalysts supported on γ-Al₂O₃