Citation: Yin-Bo Chen, Ji-Ling Li, Xu-Sheng Shao, Xiao-Yong Xu, Zhong Li. Design, synthesis and insecticidal activity of novel anthranilic diamides with benzyl sulfide scaffold[J]. Chinese Chemical Letters, ;2013, 24(8): 673-676. shu

Design, synthesis and insecticidal activity of novel anthranilic diamides with benzyl sulfide scaffold

1.
Shanghai Key Lab of Chemistry Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

Corresponding author: Zhong Li,
Received Date: 5 March 2013
Available Online: 18 April 2013

A series of novel anthranilic diamides with benzyl sulfide scaffold were synthesized, in which N-pyridylpyrazole moiety generally regarded as key pharmacophore was abandoned. The target compounds were characterized by ¹H NMR, ¹³C NMR, ¹⁹F NMR and HRMS. The preliminary bioassays indicated that half of the title compounds were endowed with good insecticidal activities against armyworm (Mythimna sepatara) at the concentration of 500 mg/L. Exhilaratingly, the synthesized compound 3a was also active against Tetranychus cinnabarinus at 100 mg/L. The difference in activities between the target compounds was influenced by the substituents, which provided some hints for further investigation on structure modifications.
- Anthranilic diamides,
- Benzyl sulfide,
- Synthesis,
- Insecticidal activity
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沈阳化工大学材料科学与工程学院沈阳 110142