Citation: Xiao-Yong Zhou, Yi-Rou Jiang, Cui-Cui Li, Xing-Yi Xie. Synthesis of poly(ethylene glycol)-functionalized hydroxyapatite organic colloid intended for nanocomposites[J]. Chinese Chemical Letters, ;2013, 24(07): 647-650. shu

Synthesis of poly(ethylene glycol)-functionalized hydroxyapatite organic colloid intended for nanocomposites

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Department of Polymeric Biomaterials and Artificial Organs, College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China

Corresponding author: Xing-Yi Xie,
Received Date: 29 January 2013
Available Online: 29 March 2013

Traditional modifications to hydroxyapatite (HA) nanoparticles usually occurred after HA synthesis and thus are insufficient to avoid particle agglomeration. In this study, a new heterofunctional poly(ethylene glycol) (PEG) with phosphoric acid and carboxyl end groups, i.e., α-(N-2-phosphoethyl phosphoric acid)-amide, ω-carboxyl-bismethyoxy poly(ethylene glycol) (ADP-PEG-COOH), was synthesized as an in situ surface modifier to HA nanoparticles. The resulting modified HA (ADP-PEG-HA) can disperse in methanol, forming a colloid stabilized by peripheral carboxyl-endcapped PEG chains. The colloidal particles resembled nanospheres which agglomerated to some extent under examination by transmission electron microscope. This highly dispersible HA nanoparticles in organic solvent might find application in preparing new HA nanocomposites.
- Poly(ethyleneglycol),
- Hydroxyapatite,
- Organic colloid,
- Nanocomposites
1. [1]
  [1] P. Zioupos, J.D. Currey, Changes in the stiffness, strength, and toughness of human cortical bone with age, Bone 22 (1998) 57-66.
2. [2]
  [2] P. Kithva, L. Grøndahl, D. Martin, et al., Biomimetic synthesis and tensile properties of nanostructured high volume fraction hydroxyapatite and chitosan biocomposite films, J. Mater. Chem. 20 (2010) 381-389.
3. [3]
  [3] R. Li, G.M. Chen, X.L. Ma, et al., Mineralization of HA crystals regulated by terephthaloyl chloride-modified silk fibroin films, Chin. Chem. Lett. 22 (2011) 1107-1110.
4. [4]
  [4] X.J. Wang, Y.B. Li, J. Wei, et al., Development of biomimetic nano-hydroxyapatite/poly(hexamethylene adipamide) composites, Biomaterials 23 (2002) 4787-4791.
5. [5]
  [5] M.Šupová, Problem of hydroxyapatite dispersion in polymer matrices: a review, J. Mater. Sci. Mater. Med. 20 (2009) 1201-1213.
6. [6]
  [6] H. Tanaka, A. Yasukawa, K. Kandori, et al., Modification of calcium hydroxyapatite using alkyl phosphates, Langmuir 13 (1997) 821-826.
7. [7]
  [7] Y.B. Li, W.J. Weng, Surface modification of hydroxyapatite by stearic acid: characterization and in vitro behaviors, J. Mater. Sci. Mater. Med. 19 (2008) 19-25.
8. [8]
  [8] Q. Liu, J.R. de Wijn, K. de Groot, et al., Surface modification of nano-apatite by grafting organic polymer, Biomaterials 19 (1998) 1067-1072.
9. [9]
  [9] X.Y. Qiu, L. Chen, J.L. Hu, et al., Surface-modified hydroxyapatite linked by L-lactic acid oligomer in the absence of catalyst, J. Polym. Sci. A: Polym. Chem. 43 (2005) 5177-5185.
10. [10]
  [10] W.B. Kong, X.Y. Zhou, Y. Yang, et al., A facile synthesis of ω-aminoalkyl ammonium hydrogen phosphates, Chin. Chem. Lett. 23 (2012) 923-926.
11. [11]
  [11] C.C. Li, L.P. Zhao, J.J. Han, et al., Synthesis of citrate-stabilized hydrocolloids of hydroxyapatite through a novel two-stage method: a possible aggregates-breakdown mechanism of colloid formation, J. Colloid Interface Sci. 360 (2011) 341-349.
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