Citation: Yi Chen Chan, Abdussalam Salhin Mohamed Ali, Melati Khairuddean, Kooi Yeong Khaw, Vikneswaran Murugaiyah, Alireza Basiri. Synthesis and molecular modeling study of Cu(Ⅱ) complexes derived from 2-(diphenylmethylene)hydrazinecarbothioamide derivatives with cholinesterase inhibitory activities[J]. Chinese Chemical Letters, ;2013, 24(07): 609-612. shu

Synthesis and molecular modeling study of Cu(Ⅱ) complexes derived from 2-(diphenylmethylene)hydrazinecarbothioamide derivatives with cholinesterase inhibitory activities

1.
a School of Chemical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia;
2.
b Discipline of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia

Corresponding author: Abdussalam Salhin Mohamed Ali,
Received Date: 29 January 2013
Available Online: 1 April 2013

Thiosemicarbazones of 2-amino-5-chlorobenzophenone and 3-aminobenzophenone (L¹-L4) have been synthesized and their Cu(Ⅱ) complexes (1-4) were afforded via coordination with cupric chloride. All these compounds were characterized by UV-vis and IR spectroscopy together with CHN elemental analysis. NMR spectroscopy was also applied to characterize the ligands. In vitro cholinesterase inhibitory assays for the complexes (1-4) showed IC₅₀ values less than 10 μmol/L, with complex 1 exhibiting the most activity, IC₅₀=2.15 μmol/L and 2.16 μmol/L for AChE and BuChE, respectively. Molecular modeling simulation revealed the binding interaction template for complex 1 with the AChE and BuChE receptors. In DPPH assay, the complexes also showed more in vitro antioxidant activities in comparison to their parent ligands.
- Thiosemicarbazone,
- Cu(Ⅱ) complex,
- Cholinesterase,
- Molecular modeling
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1.
沈阳化工大学材料科学与工程学院沈阳 110142