Login In
Citation:
Qing-Xiang Guan, De-Ya Sun, Ji-Hua Liu, Wei Li, Qin Meng, Cong Geng, Jian-Yuan Yin. A new ginsengenin containing an oxacyclopentane-ring isolated from the acid hydrolysate of total ginsenosides[J]. Chinese Chemical Letters,
;2013, 24(6): 524-526.
-
Bioassay-guided fractionation of the acid hydrolysate of total ginsenosides of Panax ginseng C.A. Meyer (Araliaceae) led to the isolation of a novel ginsengenin (1). The structure of 1 was determined as (20S,22S)-dammar-22,25-epoxy-3β,,12β,20-triol by extensive spectroscopy and single-crystal X-ray diffraction analyses. The cytotoxicity of 1 was further tested against SW1116, HCT116, and A549 cells by the MTT method, with IC50 values in the range of 2.96-30.9 μmol/L.
-
Keywords:
- Ginsengenin,
- Oxacyclopentane,
- Cytotoxicity
-
-
-
[1]
[1] C. Bachran, S. Bachran, M. Sutherland, et al., Saponins in Tumor Therapy, Mini Rev. Med. Chem. 8 (2008) 575-584.
-
[2]
[2] Z.Q. Liu, Chemical insights into ginseng as a resource for natural antioxidants, Chem. Rev. 112 (2012) 3329-3355.
-
[3]
[3] P.Y.K. Yue, N.K. Mak, Y.K. Cheng, et al., Pharmacogenomics and the yin/yang actions of ginseng: anti-tumor, angiomodulating and steroid-like activities of ginsenosides, Chin. Med. 2 (2007) 1-21.
-
[4]
[4] Y. Usami, Y.N. Liu, A.S. Lin, et al., Antitumor agents. 261. 20(S)-Protopanaxadiol and 20(S)-protopanaxatriol as antiangiogenic agents and total assignment of 1H NMR spectra, J. Nat. Prod. 71 (2008) 478-481.
-
[5]
[5] J.K. Kang, Y.J. Lee, K.O. No, et al., Ginseng intestinal metabolite-I (GIM-I) reduces doxorubicin toxicity in the mouse testis, Reprod. Toxicol. 16 (2002) 291-298.
-
[6]
[6] Y.N. Lee, H.Y. Lee, H.Y. Chung, et al., In vitro induction of differentiation by ginsenosides in F9 teratocarcinoma cells, Eur. J. Cancer 32A (1996) 1420-1428.
-
[7]
[7] L.P. Christensen, Ginsenosides: chemistry, biosynthesis, analysis, and potential health effects, Adv. Food Nutr. Res. 55 (2009) 1-100.
-
[8]
[8] L.N. Tao, Q. Meng, J.Y. Yin, et al., A new panaxadiol from the acid hydrolysate of Panax ginseng, Chin. Chem. Lett. 20 (2009) 687-689.
-
[9]
[9] S.G. Ma, Y.T. Jiang, S.J. Song, et al., Alkaline-degradation products of ginsenosides from leaves and stems of Panax quinquefolium, Acta Pharmaceut. Sinica 40 (2005) 924-930.
-
[10]
[10] L.W. Qi, C.Z. Wang, C.S. Yuan, Isolation and analysis of ginseng: advances and challenges, Nat. Prod. Rep. 28 (2011) 467-495.
-
[1]
-
-
-
[1]
Jin Wang , Xiaoyan Pan , Junyu Zhang , Qingqing Zhang , Yanchen Li , Weiwei Guo , Jie Zhang . Active molecule-based theranostic agents for tumor vasculature normalization and antitumor efficacy. Chinese Chemical Letters, 2024, 35(8): 109187-. doi: 10.1016/j.cclet.2023.109187
-
[2]
Chuan Li , Yangyang Han , Yanan Zhai , Ke Li , Xingzhong Liu , Zhuan Zhang , Cai Jia , Yongsheng Che . Phomaketals A and B, pentacyclic meroterpenoids from a eupC overexpressed mutant strain of Phoma sp.. Chinese Chemical Letters, 2024, 35(7): 109019-. doi: 10.1016/j.cclet.2023.109019
-
[3]
Jing JIN , Zhuming GUO , Zhiyin XIAO , Xiujuan JIANG , Yi HE , Xiaoming LIU . Tuning the stability and cytotoxicity of fac-[Fe(CO)3I3]- anion by its counter ions: From aminiums to inorganic cations. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 991-1004. doi: 10.11862/CJIC.20230458
-
[1]
Metrics
- PDF Downloads(0)
- Abstract views(642)
- HTML views(18)
DownLoad: