Citation: Cai-Sheng Wu, Ying Jin, Jin-Lan Zhang, Yan Ren, Zhi-Xin Jia. Simultaneous determination of seven prohibited substances in cosmetic products by liquid chromatography-tandem mass spectrometry[J]. Chinese Chemical Letters, ;2013, 24(6): 509-511. shu

Simultaneous determination of seven prohibited substances in cosmetic products by liquid chromatography-tandem mass spectrometry

1.
Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Corresponding author: Jin-Lan Zhang,
Received Date: 27 January 2013
Available Online: 8 March 2013

In this paper, we developed and validated a simple, sensitive, and selective high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method to identify and measure the following prohibited substances that may be found in cosmetic products: minoxidil, hydrocortisone, spironolactone, estrone, canrenone, triamcinolone acetonide and progesterone. Chromatographic separation was performed on a Waters Symmetry C18 (100 m×2.1 mm, 3.5 μm particle size) with a gradient elution system composed of 0.2% (v/v) formic acid aqueous solution and methanol containing 0.2% (v/v) formic acid at a flow rate of 0.3 mL/min. The substances were detected using a triple quadrupole mass spectrometer in the multiple reaction monitoring mode with an electrospray ionization source. All of the calibration curves showed good linearity (r > 0.999) within the tested concentration ranges. The limit of detection was <25 pg. The relative standard deviations for intraday precision for each of the prohibited substances were <3.5% at two concentration levels (2 μg/g, 10 μg/g). The relative recovery rate for each of the prohibited substances ranged from 91.8% to 111% at three concentration levels (0.1 μg/g, 2 μg/g, 10 μg/g), including the limit of quantification. In conclusion, we have developed and validated a method that can identify seven prohibited substances in cosmetic products.
- High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS),
- Cosmetic products,
- Prohibited substances,
- Minoxidil,
- Steroids
1. [1]
  [1] V.M. Meidan, E. Touitou, Treatments for androgenetic alopecia and alopecia areata: current options and future prospects, Drugs 61 (2001) 53-69.
2. [2]
  [2] J. Ayer, N. Burrows, Acne: more than skin deep, Postgrad. Med. J. 82 (2006) 500-506.
3. [3]
  [3] D. De Orsi, M. Pellegrini, S. Pichini, et al., High-performance liquid chromatography-diode array and electrospray-mass spectrometry analysis of non-allowed substances in cosmetic products for preventing hair loss and other hormonedependent skin diseases, J. Pharm. Biomed. Anal. 48 (2008) 641-648.
4. [4]
  [4] D. Wasserman, D.A. Guzman-Sanchez, K. Scott, A. Mcmichael, Alopecia areata, Int. J. Dermatol. 46 (2007) 121-131.
5. [5]
  [5] N. Otberg, A.M. Finner, J. Shapiro, Androgenetic alopecia, Endocrinol. Metab. Clin. North Am. 36 (2007) 379-398.
6. [6]
  [6] Q.Q. Dinh, R. Sinclair, Female pattern hair loss: current treatment concepts, Clin. Interv. Aging 2 (2007) 189.
7. [7]
  [7] S.C. Patterson, T. Ramstad, K.A. Mills, Development and validation of a procedure for the determination of minoxidil in hair-regrowth formulations using two variants of capillary zone electrophoresis, Farmaco 60 (2005) 547-554.
8. [8]
  [8] S. Gorog, Advances in the analysis of steroid hormone drugs in pharmaceuticals and environmental samples (2004-2010), J. Pharm. Biomed. Anal. 55 (2011) 728-743.
9. [9]
  [9] J.P. Scarth, J. Kay, P. Teale, et al., A review of analytical strategies for the detection of ‘endogenous' steroid abuse in food production, Drug Test. Anal. 4 (1 Suppl.) (2012) 40-49.
10. [10]
  [10] F.Z. Stanczyk, N.J. Clarke, Advantages and challenges of mass spectrometry assays for steroid hormones, J. Steroid Biochem. Mol. Biol. 121 (2010) 491-495.
11. [11]
  [11] V.M. Carvalho, The coming of age of liquid chromatography coupled to tandem mass spectrometry in the endocrinology laboratory, J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 883-884 (2012) 50-58.
12. [12]
  [12] F. Gosetti, E. Mazzucco, M.C. Gennaro, E. Marengo, Ultra high performance liquid chromatography tandem mass spectrometry determination and profiling of prohibited steroids in human biological matrices. A review. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci., in press, http://dx.doi.org/10.1016/ j.jchromb.2012.12.003.
13. [13]
  [13] Hygienic Standard for Cosmetics. Issued by the Ministry of Public Health of the People's Republic of China, 2007 version.
14. [14]
  [14] Standard Method of Determination Minoxidil in Cosmetics. Issued by the State Food and Drug Administration of the People's Republic of China, August 2010.
15. [15]
  [15] Y.S. Nam, I.K. Kwon, K.B. Lee, Monitoring of clobetasol propionate and betamethasone dipropionate as undeclared steroids in cosmetic products manufactured in Korea, Forensic Sci. Int. 210 (2011) 144-148.
16. [16]
  [16] A. Panusa, M. Ottaviani, M. Picardo, et al., Analysis of corticosteroids by high performance liquid chromatography-electrospray mass spectrometry, Analyst 129 (2004) 719-723.
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沈阳化工大学材料科学与工程学院沈阳 110142