Citation: Yan-Fang Zhao, Zi-Jian Liu, Xin Zhai, Dan-Dan Ge, Qiang Huang, Ping Gong. Synthesis and in vitro antitumor activity of novel diaryl urea derivatives[J]. Chinese Chemical Letters, ;2013, 24(05): 386-388. shu

Synthesis and in vitro antitumor activity of novel diaryl urea derivatives

1.
Key Lab of New Drugs Design and Discovery of Liaoning Province, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China

Corresponding author: Ping Gong,
Received Date: 13 December 2012
Available Online: 26 December 2012

A series of novel diaryl ureas containing 4-[(2-amino-6-trifluromethyl)pyrimidine-4-yl]piperazine-1-yl group were synthesized and evaluated for their cytotoxic activities in a panel of human cancer cell lines. Compared with the reference drug Sorafenib, some compounds showed more potent and a broader spectrum of anti-cancer activities. Among them, compound 2p demonstrated significant inhibitory activities against MDA-MB-231, HT-29 and MCF-7 cell lines with IC50 values of 0.016, 0.63, 0.001 mmol/L, respectively.
- Diaryl ureas,
- Synthesis,
- Antitumor activity in vitro
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