Citation: Yan-Wu Li, Yan Liu, Yun-Can Jia, Jian-Yong Yuan. A facile synthesis of the oxazolidinone antibacterial agent linezolid[J]. Chinese Chemical Letters, ;2013, 24(3): 230-232. shu

A facile synthesis of the oxazolidinone antibacterial agent linezolid

1.
Institute of Life Science & Pharmacy College, Chongqing Medical University, Chongqing 400016, China

Corresponding author: Jian-Yong Yuan,
Received Date: 7 December 2012
Available Online: 8 January 2013

A facile synthetic route of linezolid 1 has been developed. Using commercially available (R)-epichlorohydrin as the starting material, 1 was obtained through a sequence of cyclization, substitution, a Goldberg coupling, aminolysis and acetylation reactions. The synthetic route is easy to perform and can be scaled up.
- Linezolid,
- Synthesis,
- Goldberg coupling reaction
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1.
沈阳化工大学材料科学与工程学院沈阳 110142