Citation: Hardik H. Jardosh, Chetan B. Sangani, Manish P. Patel, Ranjan G. Patel. One step synthesis of pyrido[1,2-a]benzimidazole derivatives of aryloxypyrazole and their antimicrobial evaluation[J]. Chinese Chemical Letters, ;2013, 24(2): 123-126. shu

One step synthesis of pyrido[1,2-a]benzimidazole derivatives of aryloxypyrazole and their antimicrobial evaluation

1.
Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar-388120, Gujarat, India

Corresponding author: Manish P. Patel,
Received Date: 3 September 2012
Available Online: 31 December 2012

A new series of pyrido[1,2-a]benzimidazole derivatives bearing the aryloxypyrazole nucleus have been synthesized by base-catalyzed cyclocondensation reaction through multi-component reaction (MCR) approach. All the synthesized compounds were investigated against a representative panel of pathogenic strains using broth microdilution minimum inhibitory concentration (MIC) method for their in vitro antimicrobial activity. Reviewing the data, majority of the compounds were found to be active against employed pathogens. SAR study explores that antimicrobial activity is strongly depends on the nature of the substituents at the ether linked aryl ring attached to the pyrazole unit, together with the substituent present on the C₅ of the benzimidazole unit.
- Aryloxypyrazole,
- Pyrido[1,2-a]benzimidazole,
- Multicomponent reaction,
- Antimicrobial activity
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1.
沈阳化工大学材料科学与工程学院沈阳 110142